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Oseltamivir-resistant influenza viruses isolated in South Korea from 2005 to 2010
- Authors
- Cho, Han-Gil; Choi, Jang-Hoon; Lee, Hyun-Kyung; Mun, Su-Kyoung; Lee, Jong-Bok; Jho, Eek-Hoon; Kang, Chun; Lim, Young-Hee
- Issue Date
- Nov-2013
- Publisher
- SPRINGER WIEN
- Keywords
- Influenza viruses; Neuraminidase; Oseltamivir resistance
- Citation
- ARCHIVES OF VIROLOGY, v.158, no.11, pp.2365 - 2370
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARCHIVES OF VIROLOGY
- Volume
- 158
- Number
- 11
- Start Page
- 2365
- End Page
- 2370
- ISSN
- 0304-8608
- Abstract
- South Korean isolates of oseltamivir-resistant influenza viruses from 2005-2010 were investigated with a total 491 influenza viruses identified from 1702 specimens. Neuraminidase genes from 342 influenza viruses (71 A/H1N1, 74 pandemic A/H1N1 2009, 117 A/H3N2, and 80 B) were analyzed by RT-PCR with molecular markers for oseltamivir resistance. The H274Y mutation in the NA protein was identified in 100 % (n=40) of A/H1N1 viruses circulating in 2008-2009. Influenza A/H1N1 viruses harboring the H274Y substitution exhibited, on average, a 626-fold reduction in oseltamivir susceptibility and clustered with the A/Norway/1736/2007 strain. Close and timely monitoring for resistance to clinically available influenza antivirals should be consistently performed.
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Related Researcher
- LIM, YOUNG HEE
- College of Health Sciences (School of Biosystems and Biomedical Sciences)