Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects
- Authors
- Ju, Chung; Song, Sumi; Hwang, Sunyoung; Kim, Chorong; Kim, Minkyoung; Gu, Jail; Oh, Yu-Kyoung; Lee, Kyeong; Kwon, Jinsun; Lee, Kiho; Kim, Won-Ki; Choi, Yongseok
- Issue Date
- 1-Oct-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Cerebral ischemia; Anti-oxidant activity; Anti-excitotoxic activity; Anti-ischemic activity; Verbenone
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.19, pp.5421 - 5425
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 23
- Number
- 19
- Start Page
- 5421
- End Page
- 5425
- ISSN
- 0960-894X
- Abstract
- A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-D-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-D-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress. (C) 2013 Elsevier Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Choi, Yong seok
- College of Life Sciences and Biotechnology (Division of Biotechnology)