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Cu2+-Responsive Bimodal (Optical/MRI) Contrast Agent for Cellular Imaging
- Authors
- Jang, Joo Hee; Bhuniya, Sankarprasad; Kang, Jongeun; Yeom, Areum; Hong, Kwan Soo; Kim, Jong Seung
- Issue Date
- 20-9월-2013
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v.15, no.18, pp.4702 - 4705
- Indexed
- SCIE
SCOPUS
- Journal Title
- ORGANIC LETTERS
- Volume
- 15
- Number
- 18
- Start Page
- 4702
- End Page
- 4705
- ISSN
- 1523-7060
- Abstract
- A water-soluble T-1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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