Bone formation of middle ear cavity using biphasic calcium phosphate lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 using animal model
- Authors
- Kim, Sung Eun; Yun, Young-Pil; Song, Hae-Ryong; Choi, Kyung-Hee; Kim, Bo Hae; Lee, Eun Kyeung; Song, Jae-Jun
- Issue Date
- 9월-2013
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Otitis media; Mastoid obliteration; Scaffold; Bone morphogenetic protein
- Citation
- INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, v.77, no.9, pp.1430 - 1433
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
- Volume
- 77
- Number
- 9
- Start Page
- 1430
- End Page
- 1433
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102242
- DOI
- 10.1016/j.ijporl.2013.05.035
- ISSN
- 0165-5876
- Abstract
- Objective: The aim of the study was to analyze the value of Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2) coated biphasic calcium phosphate (BCP) for the obliteration of middle ear bone defect after mastoid surgery. Methods: Twenty-four specific pathogen-free Sprague-Dawley rats were randomly assigned to the BCP group (n = 12) and BCP-ErhBMP-2 group (n = 12; in which BCP scaffold of the granular type was coated with ErhBMP-2). In both groups, BCP scaffold was used to surgically fill the middle ear bulla. New bone formation was evaluated by measuring bone density (%) after 4 and 8 weeks in all rats in both groups. Results: At 4 weeks, new bone was visible at the periphery and center of the middle ear cavity in both groups. In the BCP group, a moderate amount of fibrous tissue had infiltrated into the interspace of the scaffolds. New bone almost totally filled the interspace in the BCP-ErhBMP-2 group. At 8 weeks, copious new bone formation had occurred. Histometric measurements showed that bone density in the BCP group was smaller than in the BCP-ErhBMP-2 group at 4 weeks (25.10% and 38.43%, respectively; p < 0.05) and 8 weeks (25.54% and 34.18%, respectively; p < 0.05). Conclusions: New bone formation was greater in the presence of BCP-ErhBMP-2 scaffolds. ErhBMP-2 coated BCP scaffolds is a potentially useful material for middle ear obliteration after mastoidectomy. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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