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Immune enhancing effect of a Maillard-type lysozyme-galactomannan conjugate via signaling pathways
- Authors
- Ha, Young-min; Chun, Su-Hyun; Hong, Seung-taek; Koo, Yun-chang; Choi, Hee-don; Lee, Kwang-won
- Issue Date
- 9월-2013
- Publisher
- ELSEVIER
- Keywords
- Galactomannan; Lysozyme; Maillard reaction; Immune-modulating effect
- Citation
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.60, pp.399 - 404
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Volume
- 60
- Start Page
- 399
- End Page
- 404
- ISSN
- 0141-8130
- Abstract
- We studied the immune-modulating effect of Maillard-type lysozyme-galactomannan conjugate (LGC). LGC significantly induced nitric oxide, and expressions of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-8 on the murine macrophage Raw 264.7 cell line. In the mechanism of LGC, while extracellular signal-regulated kinase (ERK) was important for the induction of TNF-alpha, IL-1 beta and IL-8, the phosphorylation of C-Jun NH2-termianl kinase (JNK) contributed to the induction of TNF-alpha and IL-1 beta to a greater degree. These cytokines were less sensitive to the inhibition of p38. Nuclear factor (NF)-kappa B was involved in the induction of TNF-alpha and IL-1 beta. These data indicate that LGC has immune-modulating effects via JNK, ERK and NF-kappa B pathways, and that LGC may contribute to host immune defense. (C) 2013 Elsevier B.V. All rights reserved.
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