Germinated Brown Rice Extract Inhibits Adipogenesis Through the Down-regulation of Adipogenic Genes in 3T3-L1 Adipocytes
- Authors
- Ho, Jin-Nyoung; Son, Mi-Eun; Lim, Won-Chul; Lim, Seung-Taik; Cho, Hong-Yon
- Issue Date
- 9월-2013
- Publisher
- SPRINGER
- Keywords
- Germinated brown rice; 3T3-L1; Differentiation; Adipogenesis
- Citation
- PLANT FOODS FOR HUMAN NUTRITION, v.68, no.3, pp.274 - 278
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLANT FOODS FOR HUMAN NUTRITION
- Volume
- 68
- Number
- 3
- Start Page
- 274
- End Page
- 278
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/102361
- DOI
- 10.1007/s11130-013-0366-9
- ISSN
- 0921-9668
- Abstract
- The aim of this study was to examine the anti-adipogenic effect of germinated brown rice methanol extract (GBR) in 3T3-L1 adipocytes. The GBR inhibited adipocyte differentiation was measured by Oil Red O staining and glycerol-3-phosphate dehydrogenase (GPDH) activity in a dose-dependent manner without initiating any cytotoxicity. The mRNA levels of adipogenic transcription factors such as CCAAT/enhancer binding protein (C/EBP alpha), proliferator-activated receptor gamma (PPAR gamma), and sterol regulatory element-binding protein-1c (SREBP-1c), and adipogenic genes, such as fatty acid synthase (FAS), adipocyte fatty acid-binding protein (aP2), and lipoprotein lipase (LPL), were significantly down-regulated by treatment with GBR when compared to that of untreated control cells. Moreover, tumor necrosis factor-alpha (TNF-alpha) and interlukin-6 (IL-6) mRNA expressions were attenuated by GBR in mature adipocytes. These data suggest that GBR exhibits an anti-adipogenic effect through the suppression of adipogenesis in 3T3-L1 adipocytes.
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Collections - College of Science and Technology > Department of Food and Biotechnology > 1. Journal Articles
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