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Advantages of Single-Molecule Real-Time Sequencing in High-GC Content Genomes
- Authors
- Shin, Seung Chul; Ahn, Do Hwan; Kim, Su Jin; Lee, Hyoungseok; Oh, Tae-Jin; Lee, Jong Eun; Park, Hyun
- Issue Date
- 23-7월-2013
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v.8, no.7
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLOS ONE
- Volume
- 8
- Number
- 7
- ISSN
- 1932-6203
- Abstract
- Next-generation sequencing has become the most widely used sequencing technology in genomics research, but it has inherent drawbacks when dealing with high-GC content genomes. Recently, single-molecule real-time sequencing technology (SMRT) was introduced as a third-generation sequencing strategy to compensate for this drawback. Here, we report that the unbiased and longer read length of SMRT sequencing markedly improved genome assembly with high GC content via gap filling and repeat resolution.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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