The opposite effect of isotype-selective monoamine oxidase inhibitors on adipogenesis in human bone marrow mesenchymal stem cells
- Authors
- Byun, Youngjoo; Park, Jongho; Hong, Soo Hyun; Han, Mi Hwa; Park, Suzie; Jung, Hyo-Il; Noh, Minsoo
- Issue Date
- 1-6월-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Monoamine oxidase inhibitor; Adipogenesis; Human mesenchymal stem cells; Anti-diabetes; Drug repositioning
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.11, pp.3273 - 3276
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 23
- Number
- 11
- Start Page
- 3273
- End Page
- 3276
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103002
- DOI
- 10.1016/j.bmcl.2013.03.117
- ISSN
- 0960-894X
- Abstract
- Adiponectin production during adipocyte differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) can be used to evaluate the pharmacological activity of anti-diabetic drugs to improve insulin sensitivity. Monoamine oxidase (MAO) inhibitors such as phenelzine and pargyline inhibit adipogenesis in murine pre-adipocytes. In this study, however, we found that selective MAO-A inhibitors, moclobemide and Ro41-1049, and a selective MAO-B inhibitor, selegiline, promoted adiponectin production during adipocyte differentiation in hBM-MSCs, which suggested the anti-diabetic potential of these drugs. In contrast, non-selective MAO inhibitors, phenelzine and tranylcypromine, inhibited adipocyte differentiation of hBM-MSCs. Concomitant treatments of MAO-A and MAO-B selective inhibitors did not change the stimulatory effect on adiponectin production in hBM-MSCs. Taken together, the opposite effects of isotype-selective MAO inhibitors on adiponectin production during adipogenesis in hBM-MSCs may not be directly associated with the inhibitory effects of MAO, suggested that the structure of MAO inhibitors may contain a novel anti-diabetic pharmacophore. (C) 2013 Elsevier Ltd. All rights reserved.
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