Protective Effect of beta-Caryophyllene, a Natural Bicyclic Sesquiterpene, Against Cerebral Ischemic Injury
- Authors
- Chang, Hyun-Joo; Kim, Ji-Myung; Lee, Jae-Chul; Kim, Won-Ki; Chun, Hyang Sook
- Issue Date
- 6월-2013
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- beta-caryophyllene; infarct volume; inflammatory mediators; middle cerebral artery occlusion; neuroprotective
- Citation
- JOURNAL OF MEDICINAL FOOD, v.16, no.6, pp.471 - 480
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 16
- Number
- 6
- Start Page
- 471
- End Page
- 480
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103026
- DOI
- 10.1089/jmf.2012.2283
- ISSN
- 1096-620X
- Abstract
- beta-Caryophyllene (trans-4,11,11-trimethyl-8-methylenebicyclo[7,2,0] undec-4-ene), found in various plants, is a natural bicyclic sesquiterpene with a low toxicity. Here, we show that a single intraperitoneal injection of beta-caryophyllene (10 mg/kg) significantly reduced the cortical infarct volume by 67% when given immediately before middle cerebral artery occlusion (MCAO). Neurological deficits caused by MCAO were also significantly decreased by beta-caryophyllene. beta-Caryophyllene treatment of cortical cells exposed to oxygen-glucose deprivation revealed a significant protection in a dose-dependent manner. However, beta-caryophyllene neither suppressed N-methyl-d-aspartate excitotoxicity in cultured cortical cells nor markedly decreased the oxidative stress measured in the cellular or acellular systems. By contrast, treatments with bcaryophyllene dose-dependently inhibited mRNA expression of inducible nitric oxide synthetase, interleukin (IL)-1 beta, IL-6, and cyclooxygenase 2 in C6 microglial cells, and decreased the level of nitric oxide and prostaglandin E-2 at a 100 mu M concentration. All of these findings suggest that beta-caryophyllene has a potent neuroprotective activity, and its neuroprotection may be partly related to the modulation of inflammatory mediators.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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