Angiogenesis imaging in myocardial infarction using Ga-68-NOTA-RGD PET: characterization and application to therapeutic efficacy monitoring in rats
- Authors
- Eo, Jae Seon; Paeng, Jin Chul; Lee, Song; Lee, Yun-Sang; Jeong, Jae Min; Kang, Keon Wook; Chung, June-Key; Lee, Dong Soo
- Issue Date
- 6월-2013
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- Ga-68; myocardial infarction; PET; RGD peptide; therapeutic angiogenesis
- Citation
- CORONARY ARTERY DISEASE, v.24, no.4, pp.303 - 311
- Indexed
- SCIE
SCOPUS
- Journal Title
- CORONARY ARTERY DISEASE
- Volume
- 24
- Number
- 4
- Start Page
- 303
- End Page
- 311
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/103159
- DOI
- 10.1097/MCA.0b013e3283608c32
- ISSN
- 0954-6928
- Abstract
- Objective Ga-68-NOTA-RGD PET is a newly developed molecular imaging for angiogenesis. In this study, Ga-68-NOTA-RGD PET was used to investigate imaging characteristics in a rat myocardial infarction (MI) model and to monitor the efficacy of an angiogenesis induction therapy. Materials and methods Ga-68-NOTA-RGD PET was performed serially in rats with MI or sham operation, and myocardial uptake was analyzed with respect to time duration and tissue characteristics. Subsequently, Ga-68-NOTA-RGD PET was serially performed for therapeutic efficacy monitoring in MI-induced rats, which were treated with basic fibroblast growth factor (bFGF) injection or saline injection. Image findings were compared with the final change in MI lesion. Results Ga-68-NOTA-RGD uptake was significantly increased in MI lesion and gradually decreased over time. Ga-68-NOTA-RGD uptake in the infarcted tissue corresponded with vascular endothelial growth factor expression and macrophage accumulation. In monitoring of therapeutic efficacy, the lesion uptake in the bFGF-injected group was significantly higher than that of the saline-injected and sham-operated groups on the first day. However, no significant differences were observed between bFGF and saline-injected groups at subsequent time points, corresponding to the final infarct size change. Conclusion Ga-68-NOTA-RGD PET would be a useful angiogenesis imaging modality in MI for assessment of pathophysiology or monitoring of therapeutic efficacy. Coron Artery Dis 24:303-311 (c) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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