The Role of Adiponectin in Secondary Inflammatory Reaction in Cerebral IschemiaThe Role of Adiponectin in Secondary Inflammatory Reaction in Cerebral Ischemia
- Other Titles
- The Role of Adiponectin in Secondary Inflammatory Reaction in Cerebral Ischemia
- Authors
- 정용수; 하성곤; 김상대; 김세훈; 임동준; 최종일
- Issue Date
- 2013
- Publisher
- 대한뇌혈관외과학회
- Keywords
- Adiponectin; Cerebral ischemia; Secondary inflammatory reaction; MCAO-R
- Citation
- Journal of Cerebrovascular and Endovascular Neurosurgery, v.15, no.3, pp.171 - 176
- Indexed
- KCI
OTHER
- Journal Title
- Journal of Cerebrovascular and Endovascular Neurosurgery
- Volume
- 15
- Number
- 3
- Start Page
- 171
- End Page
- 176
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/105036
- DOI
- 10.7461/jcen.2013.15.3.171
- ISSN
- 2234-8565
- Abstract
- Objective : In this study, we investigate the role of adiponectin in the interaction between leukocytes and endothelium in the secondary inflammatory reaction of cerebral ischemia Methods : Adiponectin knock-out mice group (APN-KO) (n = 8) and wild-type mice group (WT) (n = 8) were prepared. Each group was sub-divided into 2 groups by reperfusion time. One-hour middle cerebral artery occlusion and reperfusion were induced using the intraluminal filament technique. At 6 and 12 hours after the occlusion, the mice were placed on a stereotactic frame to perform craniotomy in the left parietal area. After craniotomy, a straight pial venule was selected as a target vessel. With the fluorescence intravital microscope, the number of rolling leukocytes and leukocytes that adhered to endothelium were counted and documented at 6 and 12 hours after the reperfusion.
Results : At 6 and 12 hours after the reperfusion, more rolling leukocyte and leukocyte adhesion were observed in the APN-KO mice than in the WT mice. The difference in leukocyte numbers between the APN-KO and WT mice was found to be statistically significant (p = 0.029) by Mann-Whitney U-test.
Conclusion : We found that adiponectin inhibits the interaction between the endothelium and leukocytes in cerebral ischemia-reperfusion. Therefore adiponectin might prevent the secondary insult caused by the inflammation reaction.
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