Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to vasculitis: a meta-analysis
- Authors
- Lee, Young Ho; Choi, Sung Jae; Ji, Jong Dae; Song, Gwan Gyu
- Issue Date
- 3월-2012
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Angiotensin-converting enzyme; meta-analysis; polymorphism; vasculitis
- Citation
- JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v.13, no.1, pp.196 - 201
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- Volume
- 13
- Number
- 1
- Start Page
- 196
- End Page
- 201
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/105331
- DOI
- 10.1177/1470320311434240
- ISSN
- 1470-3203
- Abstract
- Introduction: To explore whether the insertion (I) and deletion (D) polymorphism of angiotensin-converting enzyme (ACE) confers susceptibility to vasculitis. Materials and methods: A meta-analysis was conducted on the associations between the ACE I/D polymorphism and vasculitis. Results: Twelve studies, including four on Beh double dagger et's disease (BD), four on Henoch-Schenlein purpura (HSP), three on Kawasaki disease (KD), and one on Wegener's granulomatosis, were available for the meta-analysis. Meta-analysis showed that the DD + ID genotype was associated with susceptibility to vasculitis (odds ratio [OR] 1.468, 95% confidence interval [CI] 1.214-1.468, p = 7.4 x 10-5). The overall OR for the D allele was significantly increased in BD (OR 1.313, 95% CI 1.017-1.695). Meta-analysis of the DD+ID genotype, the DD genotype and the DD vs. II genotype showed marginal associations with BD, but meta-analysis of the D allele, and the DD+ID genotype showed significant associations with HSP (OR 1.446, 95% CI 1.021-2.049, p = 0.038; OR 1.881, 95% CI 1.385-2.595, p = 6.6 x 10-5). On the other hand, meta-analysis showed no association between KD and the ACE I/D polymorphism. Conclusions: This meta-analysis shows that the ACE I/D polymorphism is associated with vasculitis susceptibility, especially in BD and HSP.
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