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Cellular flavonoid transport mechanisms in animal and plant cells

Authors
Han, Y.-L.Lee, S.-Y.Lee, J.H.Lee, S.-J.
Issue Date
2013
Keywords
Animal cell; Flavonoid; Plant cell; Transport; Transporter
Citation
Korean Journal of Food Science and Technology, v.45, no.2, pp.137 - 141
Indexed
SCOPUS
KCI
Journal Title
Korean Journal of Food Science and Technology
Volume
45
Number
2
Start Page
137
End Page
141
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/105941
DOI
10.9721/KJFST.2013.45.2.137
ISSN
0367-6293
Abstract
Flavonoids have various biological activities; however, their cellular uptake mechanism is beginning to be understood only recently. This review focuses on cellular flavonoids transport mechanisms in both plants and animals. In plants, flavonoids exist in various cellular compartments, providing a specialized transport system. Newly synthesized flavonoids can be transported from the endoplasmic reticulum to the vacuoles or extracellular space via cellular trafficking pathway. Among membrane transporters, ATP binding cassette, multidrug and toxic extrusion, bilitranslocase homologue transporters play roles in both the influx and efflux of cellular flavonoids across the cell membrane. In recent years, extensive researches have provided a better understanding on the cellular flavonoid transport in mammalian cells. Bilitranslocase transports flavonoids in various tissues, including the liver, intestine and kidneys. However, other transport mechanisms are largely unknown and thus, further investigation should provide detailed mechanisms, which can potentially lead to an improved bioavailability and cellular function of flavonoids in humans.
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생명과학대학 (식품공학과)
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