Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

An innovative sample-to-answer polymer lab-on-a-chip with on-chip reservoirs for the POCT of thyroid stimulating hormone (TSH)

Authors
Jung, WooseokHan, JungyoupKai, JunhaiLim, Ji-YounSul, DonggeunAhn, Chong H.
Issue Date
2013
Publisher
ROYAL SOC CHEMISTRY
Citation
LAB ON A CHIP, v.13, no.23, pp.4653 - 4662
Indexed
SCIE
SCOPUS
Journal Title
LAB ON A CHIP
Volume
13
Number
23
Start Page
4653
End Page
4662
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/106436
DOI
10.1039/c3lc50403d
ISSN
1473-0197
Abstract
A new sample-to-answer polymer lab-on-a-chip, which can perform immunoassay with minimum user intervention through on-chip reservoirs for reagents and single-channel assay system, has been designed, developed and successfully characterized as a point-of-care testing (POCT) cartridge for the detection of thyroid stimulating hormone (TSH). Test results were obtained within 30 minutes after a sample was dropped into the POCT cartridge. The analyzed results of TSH showed a linear range of up to 55 mu IU mL(-1) with the limit of detection (LOD) of 1.9 mu IU mL(-1) at the signal-to-noise ratio (SNR) of 3. The reagents stored in the on-chip reservoirs maintained more than 97% of their initial volume for 120 days of storage time while the detection antibody retained its activity above 98% for 120 days. The sample-to-answer polymer lab-on-a-chip developed in this work using the mass-producible and low-cost polymer is well suited for the point-of-care testing of rapid in vitro diagnostics (IVD) of TSH.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Medicine > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Sul, Dong Geun photo

Sul, Dong Geun
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE