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A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells
- Authors
- Bhuniya, Sankarprasad; Lee, Min Hee; Jeon, Hyun Mi; Han, Ji Hye; Lee, Jae Hong; Park, Nayoung; Maiti, Sukhendu; Kang, Chulhun; Kim, Jong Seung
- Issue Date
- 2013
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.49, no.64, pp.7141 - 7143
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 49
- Number
- 64
- Start Page
- 7141
- End Page
- 7143
- ISSN
- 1359-7345
- Abstract
- We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug 6 in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug 6 is able to monitor drug delivery and cellular imaging.
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Collections - College of Science > Department of Chemistry > 1. Journal Articles
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