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Generation and evaluation of the efficacy of rhesus monkey soluble cytotoxic T lymphocyte-associated antigen-4 in the allogeneic mixed lymphocyte reaction
- Authors
- Kim, Jung-Sik; Choi, Inho; Lee, Han-Hyoung; Lee, Suk Jun; Na, Manheum; Kim, Sang-Hoon; Han, Jihye; Bae, Joonbeom; Choi, Sang-Pil; Kim, Sang Joon; Park, Chung-Gyu; Chun, Taehoon
- Issue Date
- 12월-2012
- Publisher
- SPRINGER
- Keywords
- Allogeneic response; Co-stimulatory molecule; Cytotoxic T lymphocyte-associated antigen-4; Mixed lymphocyte reaction; Rhesus monkey; T cells
- Citation
- BIOTECHNOLOGY LETTERS, v.34, no.12, pp.2191 - 2197
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOTECHNOLOGY LETTERS
- Volume
- 34
- Number
- 12
- Start Page
- 2191
- End Page
- 2197
- ISSN
- 0141-5492
- Abstract
- Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4; CD152) is a transmembrane protein that is structurally similar to CD28. As CTLA-4 has a much higher binding affinity to B7 than CD28, several approaches using soluble CTLA-4 have been tried to down-regulate T cell activity by blocking the interaction between CD28 and B7. We constructed soluble rhesus monkey CTLA-4 immunoglobulin (CTLA-4Ig) containing a critical binding site to B7 combined with a constant Ig heavy chain region in a mammalian system. Flow cytometry analyses indicated that soluble rhesus monkey CTLA-4Ig bound to rhesus monkey CD86 (B7.2). Moreover, soluble rhesus monkey CTLA-4Ig more effectively blocked the rhesus monkey-rhesus monkey allogeneic mixed lymphocyte reaction compared with that of humans. These results indicate that soluble rhesus monkey CTLA-4Ig may be useful in preclinical trials in a rhesus monkey model.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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