Geno-Tox: Cell Array Biochip for Genotoxicity Monitoring and Classification
- Authors
- Ahn, Joo-Myung; Gu, Man Bock
- Issue Date
- 10월-2012
- Publisher
- HUMANA PRESS INC
- Keywords
- DNA damage response; Bioluminescence bacteria; Cell array biochip
- Citation
- APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, v.168, no.4, pp.752 - 760
- Indexed
- SCIE
SCOPUS
- Journal Title
- APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
- Volume
- 168
- Number
- 4
- Start Page
- 752
- End Page
- 760
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107257
- DOI
- 10.1007/s12010-012-9815-4
- ISSN
- 0273-2289
- Abstract
- In vitro genotoxicity tests detect carcinogens that are thought to act primarily via a mechanism involving direct genetic damage. In this study, we constructed a Geno-Tox cell array chip for genotoxicity testing; eight recombinant bioluminescent bacteria were used to successfully fabricate a Geno-Tox cell array chip. Four well-characterized DNA damage chemicals were selected to determine the capabilities of this Geno-Tox array chip, and each strain of the chip was distinctly responsive, according to the specific mode of genotoxic action. Therefore, this Geno-Tox cell array chip could be implemented to characterize and understand the genotoxic modes of impact; thus, it could be used to provide the genotoxic mechanism of action for new drugs or unknown or newly synthesized chemicals in food and the environment.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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