Association between-276 C/T Polymorphism of the ERBB3 Gene and Lung Cancer Risk in a Korean Population
- Authors
- Sung, Jae Sook; Jin, Lihua; Jo, Ukhyun; Park, Kyong Hwa; Kim, Yeul Hong
- Issue Date
- 10월-2012
- Publisher
- INT INST ANTICANCER RESEARCH
- Keywords
- Lung cancer; ERBB3 gene; -276 C/T polymorphism; Korean population
- Citation
- ANTICANCER RESEARCH, v.32, no.10, pp.4433 - 4437
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANTICANCER RESEARCH
- Volume
- 32
- Number
- 10
- Start Page
- 4433
- End Page
- 4437
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107353
- ISSN
- 0250-7005
- Abstract
- Background/Aim: The associations between the polymorphisms in the promoter region of the V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ERBB3) gene and lung cancer risk were investigated. Materials and Methods: By direct sequencing, we first found two known polymorphisms (-536 A/G and -276 C/T. Further TaqMan assays and logistic regression analyses were performed in order to characterize the association between the -276 C/T polymorphism of ERBB3 and lung cancer risk in 425 patients with lung cancer and 411 healthy controls. To examine the potential effects of the -276 C/T polymorphism on ERBB3 transcription, luciferase reporter assays were performed in non-small cell lung cancer (NSCLC) cell lines. Results: The -276 C/T polymorphism was associated with the risk of lung cancer in a recessive model of never-smokers. Interestingly, the T allele conferred significantly lower promoter activity by 32% and 33% than the C allele in H2009 and H358 cell lines. Conclusion: ERBB3 promoter polymorphisms affect ERBB3 gene expression, and contribute to genetic susceptibility to lung cancer in never-smokers.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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