Expression of estrogen receptors in gastric cancer and their clinical significance
- Authors
- Ryu, Woo-Sang; Kim, Jong-Han; Jang, You-Jin; Park, Sung-Soo; Um, Jun-Won; Park, Seong-Heum; Kim, Seung-Joo; Mok, Young-Jae; Kim, Chong-Suk
- Issue Date
- 9월-2012
- Publisher
- WILEY
- Keywords
- estrogen receptor a; estrogen receptor ss; gastric cancer
- Citation
- JOURNAL OF SURGICAL ONCOLOGY, v.106, no.4, pp.456 - 461
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF SURGICAL ONCOLOGY
- Volume
- 106
- Number
- 4
- Start Page
- 456
- End Page
- 461
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107489
- DOI
- 10.1002/jso.23097
- ISSN
- 0022-4790
- Abstract
- Backgrounds and Objectives The male predominance of gastric cancer suggests that female sex hormones may have a protective effect against gastric cancer. We evaluated the expression of estrogen receptors in gastric cancer tissue and cells and the clinical significance of ER-beta expression in gastric cancer. Method ER-alpha, ER-beta proteins extracted from normal stomach, gastric cancer tissues, and cultured gastric cancer cells (KATO-III, mkn28, mkn45, and mkn74) were assessed by Western blot analysis. The clinical significance of ER-beta was explored using tissue microarray methods and immunohistochemical staining of specimens from 148 gastric cancers. Results Both ER-alpha and beta protein expression were noted in normal and gastric cancer tissues. However, in cultured gastric cells, only ER-beta was noted in mkn28 and mkn74. Of 148 gastric cancers, 67 (45.3%) were ER-beta positive. The ER-beta positive group was associated with lower tumor stage, Lauren's intestinal type, negative perineural invasion, and free of recurrence. The ER-beta positive group had a better 3-year survival compared with the negative group in survival analysis. Conclusion Our results suggest that the presence of ER-beta in gastric cancer could have a protective effect against invasiveness of gastric cancer. Further studies are needed to clarify the role of ER-beta in gastric cancers. J. Surg. Oncol. 2012; 106:456461. (c) 2012 Wiley Periodicals, Inc.
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