Docetaxel-loaded composite nanoparticles formed by a temperature-induced phase transition for cancer therapy
- Authors
- Yuk, Soon H.; Oh, Keun S.; Park, Jinah; Lee, Eun H.; Kim, Kwangmeyung; Kwon, Ick C.
- Issue Date
- 9월-2012
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Composite nanoparticles; docetaxel; in vivo biodistribution; Tween 80/soybean oil; antitumor efficacy; cancer therapy
- Citation
- JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, v.27, no.5, pp.441 - 452
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
- Volume
- 27
- Number
- 5
- Start Page
- 441
- End Page
- 452
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107587
- DOI
- 10.1177/0883911512448752
- ISSN
- 0883-9115
- Abstract
- Docetaxel-loaded composite nanoparticles were prepared by temperature-induced phase transition of a mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing docetaxel. Liquid soybean oil/Tween 80 was used as a solubilizer for docetaxel and Pluronic F-68 to stabilize the liquid soybean oil/Tween 80 containing docetaxel. The phase transition was performed at low temperature to avoid degradation. The docetaxel composite nanoparticles were injected into the tail veins of tumor-bearing mice to evaluate the composite delivery system for the release pattern and the tumor growth. The tumor-targeting capability of composite nanoparticles was verified by noninvasive live animal imaging for the time-dependent excretion profile, the in vivo biodistribution, and the circulation time.
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- Appears in
Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
- Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles
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