N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression
- Authors
- Kang, Hyereen; Lee, Minjae; Choi, Kyung-chul; Shin, Dong-Myoung; Ko, Jesang; Jang, Sung-Wuk
- Issue Date
- 9월-2012
- Publisher
- WILEY
- Keywords
- 4-HPR; MMP-9; CELL INVASION; NF-?B; BREAST CANCER
- Citation
- JOURNAL OF CELLULAR BIOCHEMISTRY, v.113, no.9, pp.2845 - 2855
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CELLULAR BIOCHEMISTRY
- Volume
- 113
- Number
- 9
- Start Page
- 2845
- End Page
- 2855
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107592
- DOI
- 10.1002/jcb.24159
- ISSN
- 0730-2312
- Abstract
- Synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) has been reported to exhibit anti-invasive and anti-metastatic activities by suppressing the enzymatic activity of matrix metalloproteinase (MMP)-9, but the underlying mechanism remains unclear. Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells. 4-HPR inhibits the transcriptional activity of MMP-9 by reducing the DNA-binding activity of NF-?B on the MMP-9 promoter as well as by inhibiting the degradation of I?Ba, leading to cytoplasmic accumulation of NF-?B. We also found that 4-HPR inhibits invasion and MMP-9 expression in the highly metastatic breast cancer cell line MDA-MB-231. Thus, 4-HPR might be a potent anti-invasive agent that works by suppressing MMP-9 expression via the NF-?B signaling pathway. J. Cell. Biochem. 113: 28452855, 2012. (C) 2012 Wiley Periodicals, Inc.
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