The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: A meta-analysis
- Authors
- Lea, Wu-in; Lee, Young Ho
- Issue Date
- 7월-2012
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Keywords
- Interleukin-1; Polymorphism; Ankylosing spondylitis; Meta-analysis
- Citation
- JOINT BONE SPINE, v.79, no.4, pp.370 - 374
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOINT BONE SPINE
- Volume
- 79
- Number
- 4
- Start Page
- 370
- End Page
- 374
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108039
- DOI
- 10.1016/j.jbspin.2011.06.010
- ISSN
- 1297-319X
- Abstract
- Objective: The aim of this study was to determine whether polymorphisms of interleukin-1 (IL-1) confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted meta-analyses on associations between IL-1 polymorphisms and AS susceptibility, using fixed or random effects models. In order to avoid duplications and data previously subjected to meta-analysis, we performed meta-analysis on studies if new data on IL-1 polymorphisms in AS were reported. Results: A total of nine studies consisting of 20 separate comparisons of association between IL-1 polymorphisms and AS susceptibility were included in this meta-analysis. These were performed on European, Asian, and Latin American population samples. Meta-analysis revealed a significant association between the 2 allele of the IL-1F10.3 polymorphism (rs3811581) and the risk of developing AS in Europeans (OR = 0.775, 95% CI = 0.605-0.992, P = 0.043). Furthermore, the OR of the 2 allele of IL-1A + 889 (rs1800587) was found to be significantly increased in Europeans with AS (OR = 1.357, 95% CI = 1.085-1.697, P = 0.007). However, meta-analyses of the IL-1B-511, IL-1B + 3953, and ILF7.1 polymorphisms and of the variable numbers of tandem repeats of the IL-1 receptor antagonist gene (IL-1RN VNTR) revealed no association between AS and these polymorphisms. Conclusions: In addition to the three known IL-1 polymorphisms, rs2856836, rs17561, and rs1894399, found in previous meta-analysis, this meta-analysis shows that the IL-1F10.3 and IL-1A + 889 polymorphisms are associated with the development of AS in Europeans but not in Asians. (C) 2011 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
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