Hypoglycemia is associated with increased worry and lower quality of life among patients with type 2 diabetes treated with oral antihyperglycemic agents in the Asia-Pacific region
- Authors
- Sheu, Wayne H. -H.; Ji, Li-Nong; Nitiyanant, Wannee; Baik, Sei Hyun; Yin, Donald; Mavros, Panagiotis; Chan, Siew-Pheng
- Issue Date
- 5월-2012
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Hypoglycemia; Diabetes; Worry; Quality of life
- Citation
- DIABETES RESEARCH AND CLINICAL PRACTICE, v.96, no.2, pp.141 - 148
- Indexed
- SCIE
SCOPUS
- Journal Title
- DIABETES RESEARCH AND CLINICAL PRACTICE
- Volume
- 96
- Number
- 2
- Start Page
- 141
- End Page
- 148
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108574
- DOI
- 10.1016/j.diabres.2011.12.027
- ISSN
- 0168-8227
- Abstract
- Aims: We examined the relationship of hypoglycemic symptoms with health-related quality of life and worry about hypoglycemia among type 2 diabetic patients using oral anti-hyperglycemic agents (AHA) in the Asia-Pacific region. Methods: A total of 2257 type 2 diabetic patients with at least 6 months of oral AHA were enrolled in China, Korea, Malaysia, Thailand, and Taiwan. Quality of life was measured with the EuroQol Visual Analog Scale (EQ-VAS) and EuroQol-5 Dimensions questionnaire (EQ-5D), and worry about hypoglycemia with the worry subscale of the Hypoglycemic Fear Survey-II (HFS). Results: The mean (SD) age was 58.7 (10.2) years and HbA(1c) was 7.5% (1.5). The proportion of patients with an HbA(1c) <6.5% and <7% was 24.9% and 41.8%, respectively. Hypoglycemic symptoms in the prior 6 months were reported by 35.8% of patients. Mean scores on the EQ-VAS and the EQ-5D were significantly lower for patients who had hypoglycemic symptoms compared to those who did not (73.6 vs. 76.9, p < 0.001; 0.88 vs. 0.90, p < 0.0001, respectively), whereas mean score on the HFS was significantly higher (12.5 vs. 6.3, p < 0.001). In multi-variate models, hypoglycemic symptoms were independently associated with scores on the EQ-5D, EQ-VAS, and HFS (all p < 0.01-0.001). Symptom severity was positively associated with fear of hypoglycemia (all p <= 0.001). Conclusion: Hypoglycemic symptoms were associated with reduced quality of life and increased patient worry in patients with type 2 diabetes treated with AHA. (C) 2012 Published by Elsevier Ireland Ltd.
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