Paclitaxel-loaded poly(lactide-co-glycolide)/poly(ethylene vinyl acetate) composite for stent coating by ultrasonic atomizing spray
- Authors
- Yuk, Soon Hong; Oh, Keun Sang; Park, Jinah; Kim, Soon-Joong; Kim, Jung Ho; Kwon, Il Keun
- Issue Date
- Apr-2012
- Publisher
- NATL INST MATERIALS SCIENCE
- Keywords
- PLGA/PEVA composite; drug-eluting stents; paclitaxel; sustained release; ultrasonic atomizing spray
- Citation
- SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, v.13, no.2
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
- Volume
- 13
- Number
- 2
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108805
- DOI
- 10.1088/1468-6996/13/2/025005
- ISSN
- 1468-6996
- Abstract
- The mixture of poly(lactide-co-glycolide) (PLGA) and poly(ethylene vinyl acetate) (PEVA) forms a homogeneous liquid in an organic solvent such as tetrahydrofuran, and a phase-separated PLGA/PEVA composite can be prepared from it by evaporating the organic solvent. Exploiting this phenomenon, we designed a novel method of preparing a drug-loaded PLGA/PEVA composite and used it for coating drug-eluting stents (DESs). Paclitaxel (PTX), an anticancer drug, was chosen as a model drug. PLGA acts as a microdepot for PTX, and PEVA provides mechanical strength to the coating material. The presence of PLGA in the PLGA/PEVA composite suppressed PTX crystallization in the coating material, and PTX showed a sustained release rate over more than 30 days. The mechanical strength of the PLGA/PEVA composite was better than that of PEVA used as a control. After coating the stent with a PLGA/PEVA composite using ultrasonic atomizing spray, the morphology of the coated material was observed by scanning electron microscopy, and the release pattern of PTX was measured by high-performance liquid chromatography.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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