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Multi-core vesicle nanoparticles for controlled delivery of protein drug
- Authors
- Yuk, Soon Hong; Oh, Keun Sang; Kim, Seung Ki; Lee, Jin Ho; Cho, Sun Hang; Kim, Kwangmeyung; Jeon, Hyesung; Kwon, Ick Chan
- Issue Date
- Mar-2012
- Publisher
- POLYMER SOC KOREA
- Keywords
- human growth hormone; Pluronic/PEG composite NPs; multi-core vesicle NPs; peptide drug; sustained release
- Citation
- MACROMOLECULAR RESEARCH, v.20, no.3, pp.309 - 312
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MACROMOLECULAR RESEARCH
- Volume
- 20
- Number
- 3
- Start Page
- 309
- End Page
- 312
- ISSN
- 1598-5032
- Abstract
- The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.
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Related Researcher
- Yuk, Soon Hong
- College of Pharmacy (Department of Pharmaceutical Science)