Extremely Low Frequency Magnetic Fields Do Not Elicit Oxidative Stress in MCF10A Cells
- Authors
- Hong, Mi-Na; Han, Na-Kyung; Lee, Hyung-Cgul; Ko, Young-Kyu; Chi, Sung-Gil; Lee, Yun-Sil; Gimm, Yoon-Myung; Myung, Sung-Ho; Lee, Jae-Seon
- Issue Date
- Jan-2012
- Publisher
- OXFORD UNIV PRESS
- Keywords
- ELF-MF; Oxidative stress; MCF10A cells
- Citation
- JOURNAL OF RADIATION RESEARCH, v.53, no.1, pp.79 - 86
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF RADIATION RESEARCH
- Volume
- 53
- Number
- 1
- Start Page
- 79
- End Page
- 86
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/109156
- DOI
- 10.1269/jrr.11049
- ISSN
- 0449-3060
- Abstract
- The aim of this study was to determine whether extremely low frequency magnetic fields (ELF-MF) could affect intracellular reactive oxygen species (ROS) levels and antioxidant enzyme activity. After MCF10A human breast epithelial cells were exposed to 1 mT of 60 Hz ELF-MF for 4 hours, intracellular ROS level, superoxide dismutase (SOD) activity, and reduced to oxidized glutathione (GSH/GSSG) ratio were measured. The cells exposed to ELF-MF did not evidence statistically significant changes in the above-mentioned biological parameters as compared to either the incubator controls or sham-exposed cells. By way of contrast, the IR-exposed cells exhibited marked changes in ROS level, SOD activity, and GSH/GSSG ratio. When we assessed morphological changes and senescence-associated beta-galactosidase (SA-beta-Gal) activity, only the IR-exposed cells were positive. According to our results, it could be concluded that ELF-MF has no effect on intracellular ROS level, SOD activity, and GSH/GSSG ratio under our exposure condition.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholar.korea.ac.kr/handle/2021.sw.korea/109156)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.