Prognostic Impact of Fascin-1 Expression is More Significant in Advanced Colorectal Cancer
- Authors
- Oh, Seung Yeop; Kim, Young Bae; Suh, Kwang Wook; Paek, Ok Joo; Moon, Hong Young
- Issue Date
- 1월-2012
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- fascin-1; beta-catenin; Immunohistochemical staining; colorectal cancer
- Citation
- JOURNAL OF SURGICAL RESEARCH, v.172, no.1, pp.102 - 108
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF SURGICAL RESEARCH
- Volume
- 172
- Number
- 1
- Start Page
- 102
- End Page
- 108
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/109175
- DOI
- 10.1016/j.jss.2010.07.015
- ISSN
- 0022-4804
- Abstract
- Background. Fascin-1 is not expressed in normal colorectal epithelium, but is up-regulated in colorectal cancer. However, its exact biological mechanism remains unknown. The purpose of this study was to investigate the relationship of fascin-1 expression with the clinicopathologic parameters and its prognostic impact in advanced colorectal cancer. Materials and Methods. The immunohistochemical stainings for fascin-1, beta-catenin, and Ki-67 labeling index were performed with 126 stage III colorectal cancer specimens. Results. Fascin-1 was found to be expressed in 74 (58.7%) of the 126 colorectal cancer specimens. Five-year survival rate was significantly low, whereas the distant recurrence rate was significantly high in patients with fascin-positive stage III colorectal cancer. There was no significant correlation between fascin-1 expression and clinicopathologic factors such as tumor size, nodal metastasis, pathologic stage, beta-catenin expression, and Ki-67 labeling index. However, fascin-1 expression was an independent prognostic factor in multivariate analysis. Patients with N1 showed no significant difference in 5-y DFS and OS according to the fascin-1 expression (79.0% versus 60.5%, P = 0.113; 86.5% versus 78.8%, P = 0.566). Patients with N2 showed marginal difference in 5-y DFS and significant difference in 5-y OS according to the fascin-1 expression (59.4% versus 32.4%, P = 0.088; 81.2% versus 39.5%, P = 0.002). Conclusions. This study suggests that fascin-1 expression in colorectal cancer may be clinically useful in predicting distant metastasis and poor survival, and we demonstrated that fascin-1 expression and N stage are significant independent prognostic factors for survival of colorectal cancer patients. (C) 2012 Elsevier Inc. All rights reserved.
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