Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents
- Authors
- Hyun, Sei Eun; Lee, Byung Churl; Suh, Byung Kyu; Chung, So Chung; Ko, Cheol Woo; Kim, Heung Sik; Lee, Kee Hyoung; Yang, Sei Won; Shin, Choong Ho; Hwang, Jin Soon; Kim, Duk Hee; Lim, Baek Keun; Kim, Jong Duck; Yoo, Han-Wook; Kim, Hye Soon; Chung, Woo Yeong; Park, Mi Jung; Woo, Young Jong; Kim, Chan Jong; Lee, Dae-Yeol; Kim, Eun Young; Choi, Jin Ho; Han, Heon Seok; Hwang, Il Tae; Kim, Ho-Seong
- Issue Date
- Jan-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- IGF-I; IGFBP-3; Korean; Child; Adolescent
- Citation
- CLINICAL BIOCHEMISTRY, v.45, no.1-2, pp.16 - 21
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL BIOCHEMISTRY
- Volume
- 45
- Number
- 1-2
- Start Page
- 16
- End Page
- 21
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/109234
- DOI
- 10.1016/j.clinbiochem.2011.10.003
- ISSN
- 0009-9120
- Abstract
- Objective: Measurements of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are utilized in the diagnostic work-up and clinical management of children with growth disorders. We designed this study to establish the reference values of serum IGF-I and IGFBP-3 levels according to age, sex and pubertal stage in Korean children and adolescents. Methods: For the study, 1378 healthy Korean children and adolescents aged 0 to 17 years (722 boys, 656 girls) were randomly selected. Blood samples were collected, and the stored sera were assayed for IGF-I and IGFBP-3 using immunoradiometric assay (IRMA, Immunotech). The R 2.8.1 program (Bell Laboratories) was used to generate reference percentile curves for IGF-I and IGFBP-3 according to age, sex, and pubertal stage Results: Serum IGFBP-3 level was higher in girls compared to that in boys of the same ages throughout the pubertal period, whereas IGF-I was only higher for girls younger than 13 years of age. Serum levels of IGF-I and IGFBP-3 increased steadily with age in the prepubertal stage, followed by a progressive decline thereafter. Peak levels of serum IGF-I and IGFBP-3 were observed two years earlier in girls compared to those in boys (13 vs. 15 years of age, respectively). Serum IGF-I and IGFBP-3 concentrations were highest at Tanner stage IV in boys and girls, with a subsequent decline. Conclusions: Our reference value model based on age, sex, and pubertal stage can improve the diagnostic utility of IGF-I and IGFBP-3 levels in the evaluation and management of Korean children and adolescents with growth disorders. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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