Effectiveness and Safety of Thrombolysis in Ischemic Stroke Patients Aged 80 Years or OlderEffectiveness and Safety of Thrombolysis in Ischemic Stroke Patients Aged 80 Years or Older
- Other Titles
- Effectiveness and Safety of Thrombolysis in Ischemic Stroke Patients Aged 80 Years or Older
- Authors
- 김욱주; 권오기; 오창완; 정철규; 이지성; 이준영; 박정현; 고영채; 장명숙; 양미화; 한문구; 배희준
- Issue Date
- 2012
- Publisher
- 대한뇌졸중학회
- Keywords
- Thrombolysis; Treatment outcome; Aged 80 and over
- Citation
- 대한뇌졸중학회지, v.14, no.1, pp.19 - 28
- Indexed
- KCI
OTHER
- Journal Title
- 대한뇌졸중학회지
- Volume
- 14
- Number
- 1
- Start Page
- 19
- End Page
- 28
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/109543
- DOI
- 10.5853/kjs.2012.14.1.19
- ISSN
- 2287-6391
- Abstract
- Background: Thrombolysis becomes an emerging therapeutic option for acute ischemic stroke. However, few reports exist on its use in the very elderly. We investigated whether there is a difference in the effectiveness and safety of intravenous (IV) and/or intra-arterial (IA) thrombolysis between patients aged ≥80 years and those aged <80 years. Methods: A consecutive series of patients hospitalized within 12 hours from stroke onset were selected. We evaluated the effectiveness of thrombolysis with modifi ed Rankin scale (mRS) at 3 months, and the safety with symptomatic hemorrhagic transformation (sHT). The odds ratio (OR)of thrombolysis on the favorable mRS (0-2) was calculated using multivariable logistic regression analysis with adjustments for potential confounders. Whether the effectiveness of thrombolysis is age-dependent or not was analyzed by introducing an interaction term (thrombolysis×age group) into multivariable models. Results: Among 219 patients ≥80 years, 21% of patients received IV or IA or combined thrombolysis while 23% of 980 patients <80 years received thrombolysis (P =0.51). With respect to the favorable mRS, the adjusted ORs of thrombolysis were 1.70 (95% confi dence interval, 1.08-2.68) in all subjects, 1.61(0.58-4.49) in those ≥80 years, and 1.71 (1.05-2.78) in those <80 years. There was no signifi cant interaction between age group and thrombolysis (P =0.91). With respect to sHT, the adjusted OR was 4.72 (1.94-11.45) in all subjects with no signifi cant interaction (P =0.86). Conclusion: This study suggests that thrombolysis may be equally safe and effective in stroke patients aged ≥80 years versus <80 years.
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