Antiulcer Activity of Anthocyanins from Rubus coreanus via Association with Regulation of the Activity of Matrix Metalloproteinase-2
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sun-Joong | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Kim, Bum-Soo | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Lee, Sung-Joon | - |
dc.contributor.author | Yoo, Sang-Ho | - |
dc.contributor.author | Chang, Hyo Ihl | - |
dc.date.accessioned | 2021-09-07T06:18:50Z | - |
dc.date.available | 2021-09-07T06:18:50Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-11-09 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111156 | - |
dc.description.abstract | Anthocyanins were extracted from the fruits of Rubus coreanus. Whether their antioxidant properties and antiulcer activity in gastric ulceration have been accompanied by the activation of matrix metalloproteainse-2 (MMP-2) was investigated. To assess the effect of anthocyanins on gastric ulcer, the rats were administered with anthocyanins (20, 50, and 80 mg/kg of body weight) before treatment with naproxen (80 mg/kg of body weight) to induce gastric ulceration. Lipid peroxidation and the activities of radical scavenging enzymes such as catalase, superoxide dismutase, and glutathione peroxidase were determined. The MMP-2 level was tested by zymography and Western blot. Anthocyanins of R. coreanus exhibit possible antiulcer activity in acute ulcer in a rat model by preventing lipid peroxidation and a significant increase in the activities of antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase. Also, anthocyanins induce activation of MMP-2 and attenuate the activity of the proinflammatory molecules, such as tumor necrosis factor-alpha and interleukin-1 beta. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | INDUCED GASTRIC-ULCER | - |
dc.subject | GASTROINTESTINAL DAMAGE | - |
dc.subject | ANTIOXIDANT PROPERTIES | - |
dc.subject | IN-VITRO | - |
dc.subject | MELATONIN | - |
dc.subject | INDOMETHACIN | - |
dc.subject | RAT | - |
dc.subject | PREVENTION | - |
dc.subject | LESIONS | - |
dc.title | Antiulcer Activity of Anthocyanins from Rubus coreanus via Association with Regulation of the Activity of Matrix Metalloproteinase-2 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sung-Joon | - |
dc.contributor.affiliatedAuthor | Chang, Hyo Ihl | - |
dc.identifier.doi | 10.1021/jf104192a | - |
dc.identifier.scopusid | 2-s2.0-80455178466 | - |
dc.identifier.wosid | 000296312000053 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.59, no.21, pp.11786 - 11793 | - |
dc.relation.isPartOf | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 59 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 11786 | - |
dc.citation.endPage | 11793 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | INDUCED GASTRIC-ULCER | - |
dc.subject.keywordPlus | GASTROINTESTINAL DAMAGE | - |
dc.subject.keywordPlus | ANTIOXIDANT PROPERTIES | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | MELATONIN | - |
dc.subject.keywordPlus | INDOMETHACIN | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordAuthor | Anthocyanins | - |
dc.subject.keywordAuthor | gastric ulcer | - |
dc.subject.keywordAuthor | matrix metalloprotenase-2 | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.