Antiulcer Activity of Anthocyanins from Rubus coreanus via Association with Regulation of the Activity of Matrix Metalloproteinase-2
- Authors
- Kim, Sun-Joong; Lee, Hyun Ju; Kim, Bum-Soo; Lee, Dongho; Lee, Sung-Joon; Yoo, Sang-Ho; Chang, Hyo Ihl
- Issue Date
- 9-11월-2011
- Publisher
- AMER CHEMICAL SOC
- Keywords
- Anthocyanins; gastric ulcer; matrix metalloprotenase-2; reactive oxygen species
- Citation
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.59, no.21, pp.11786 - 11793
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Volume
- 59
- Number
- 21
- Start Page
- 11786
- End Page
- 11793
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111156
- DOI
- 10.1021/jf104192a
- ISSN
- 0021-8561
- Abstract
- Anthocyanins were extracted from the fruits of Rubus coreanus. Whether their antioxidant properties and antiulcer activity in gastric ulceration have been accompanied by the activation of matrix metalloproteainse-2 (MMP-2) was investigated. To assess the effect of anthocyanins on gastric ulcer, the rats were administered with anthocyanins (20, 50, and 80 mg/kg of body weight) before treatment with naproxen (80 mg/kg of body weight) to induce gastric ulceration. Lipid peroxidation and the activities of radical scavenging enzymes such as catalase, superoxide dismutase, and glutathione peroxidase were determined. The MMP-2 level was tested by zymography and Western blot. Anthocyanins of R. coreanus exhibit possible antiulcer activity in acute ulcer in a rat model by preventing lipid peroxidation and a significant increase in the activities of antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase. Also, anthocyanins induce activation of MMP-2 and attenuate the activity of the proinflammatory molecules, such as tumor necrosis factor-alpha and interleukin-1 beta.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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