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Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs
- Issue Date
- Nov-2011
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Drug delivery; Multi-core vesicle nanoparticles; Pluronic; Docetaxel; Chemotherapy
- Citation
- BIOMATERIALS, v.32, no.31, pp.7924 - 7931
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMATERIALS
- Volume
- 32
- Number
- 31
- Start Page
- 7924
- End Page
- 7931
- ISSN
- 0142-9612
- Abstract
- The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTX-loaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a non-invasive live animal imaging technology. (C) 2011 Elsevier Ltd. All rights reserved.
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Related Researcher
- Yuk, Soon Hong
- College of Pharmacy (Department of Pharmaceutical Science)