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Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging
- Authors
- Lim, Eun-Kyung; Kim, Hyun-Ouk; Jang, Eunji; Park, Joseph; Lee, Kwangyeol; Suh, Jin-Suck; Huh, Yong-Min; Haam, Seungjoo
- Issue Date
- 11월-2011
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Hyaluronan; Magnetic resonance imaging; Magnetic nanoclusters; CD44; Breast cancer
- Citation
- BIOMATERIALS, v.32, no.31, pp.7941 - 7950
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMATERIALS
- Volume
- 32
- Number
- 31
- Start Page
- 7941
- End Page
- 7950
- ISSN
- 0142-9612
- Abstract
- We fabricated hyaluronan-modified magnetic nanoclusters (HA-MNCs) for detection of CD44-overexpressing breast cancer using magnetic resonance (MR) imaging. CD44 is closely associated with cancer growth, including proliferation, metastasis, invasion, and angiogenesis. Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Subsequently. HA-MNCs were fabricated using the nano-emulsion method; magnetic nanocrystals were simultaneously self-assembled with Py-HA conjugates, and their physical and magnetic properties depended on the degree of substitution (DS) of Py in Py-HA conjugates. HA-MNCs exhibited superior targeting efficiency with MR sensitivity as well as excellent biocompatibility through in vitro/in vivo studies. This suggests that HA-MNCs can be a potent cancer specific molecular imaging agent via targeted detection of CD44 with MR imaging. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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