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Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging

Authors
Lim, Eun-KyungKim, Hyun-OukJang, EunjiPark, JosephLee, KwangyeolSuh, Jin-SuckHuh, Yong-MinHaam, Seungjoo
Issue Date
11월-2011
Publisher
ELSEVIER SCI LTD
Keywords
Hyaluronan; Magnetic resonance imaging; Magnetic nanoclusters; CD44; Breast cancer
Citation
BIOMATERIALS, v.32, no.31, pp.7941 - 7950
Indexed
SCIE
SCOPUS
Journal Title
BIOMATERIALS
Volume
32
Number
31
Start Page
7941
End Page
7950
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/111199
DOI
10.1016/j.biomaterials.2011.06.077
ISSN
0142-9612
Abstract
We fabricated hyaluronan-modified magnetic nanoclusters (HA-MNCs) for detection of CD44-overexpressing breast cancer using magnetic resonance (MR) imaging. CD44 is closely associated with cancer growth, including proliferation, metastasis, invasion, and angiogenesis. Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Subsequently. HA-MNCs were fabricated using the nano-emulsion method; magnetic nanocrystals were simultaneously self-assembled with Py-HA conjugates, and their physical and magnetic properties depended on the degree of substitution (DS) of Py in Py-HA conjugates. HA-MNCs exhibited superior targeting efficiency with MR sensitivity as well as excellent biocompatibility through in vitro/in vivo studies. This suggests that HA-MNCs can be a potent cancer specific molecular imaging agent via targeted detection of CD44 with MR imaging. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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