Digitally tunable physicochemical coding of material composition and topography in continuous microfibres
- Authors
- Kang, Edward; Jeong, Gi Seok; Choi, Yoon Young; Lee, Kwang Ho; Khademhosseini, Ali; Lee, Sang-Hoon
- Issue Date
- 11월-2011
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE MATERIALS, v.10, no.11, pp.877 - 883
- Indexed
- SCIE
SCOPUS
- Journal Title
- NATURE MATERIALS
- Volume
- 10
- Number
- 11
- Start Page
- 877
- End Page
- 883
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111237
- DOI
- 10.1038/NMAT3108
- ISSN
- 1476-1122
- Abstract
- Heterotypic functional materials with compositional and topographical properties that vary spatiotemporally on the micro- or nanoscale are common in nature. However, fabricating such complex materials in the laboratory remains challenging. Here we describe a method to continuously create microfibres with tunable morphological, structural and chemical features using a microfluidic system consisting of a digital, programmable flow control that mimics the silk-spinning process of spiders. With this method we fabricated hydrogel microfibres coded with varying chemical composition and topography along the fibre, including gas micro- bubbles as well as nanoporous spindle-knots and joints that enabled directional water collection. We also explored the potential use of the coded microfibres for tissue engineering applications by creating multifunctional microfibres with a spatially controlled co-culture of encapsulated cells.
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Collections - College of Health Sciences > School of Biomedical Engineering > 1. Journal Articles
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