Red Yeast Barley Reduces Plasma Glucose Levels and Activates AMPK Phosphorylation in db/db Mice
- Authors
- Jun, Hee-jin; Choi, Young-Mi; Hoang, Minh Hien; Jia, Yoayao; Lee, Ji Hae; Lee, Sung-Joon
- Issue Date
- 11월-2011
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- Monascus purpureus; red yeast; barley; glucose tolerance; AMP-activated protein kinase (AMPK)
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.20, no.5, pp.1265 - 1270
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 20
- Number
- 5
- Start Page
- 1265
- End Page
- 1270
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111327
- DOI
- 10.1007/s10068-011-0174-7
- ISSN
- 1226-7708
- Abstract
- Red yeast (Monascus purpureus) fermented over rice has a limited hypoglycemic activity. To enhance its glucose-lowering effect, we fermented red yeast over waxy barley, a hypoglycemic grain with high levels of fibers and beta-glucans, and investigated the metabolic effects of red yeast barley (RYB) in high-fat-fed hyperglycemic db/db mice for 6 weeks. The fasting glucose levels were significantly reduced in the RYB group at 6 weeks by 25% (p<0.05), as was the glucose tolerance (-27% of area under the curve in RYB vs. controls, p<0.05). Plasma insulin levels and the expression of PPAR-gamma were unaltered, however, the phosphorylation activation of hepatic AMP-activated protein kinase (AMPK) was increased significantly in RYB group compared with controls suggesting that hypoglycemic effect of RYB may be achieved by AMPK-dependent mechanism. RYB may be used as a hypoglycemic functional food modulating cellular AMPK activity.
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