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The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis
- Authors
- Lim, Do-Hwan; Oh, Chun-Taek; Lee, Langho; Hong, Jae-Sang; Noh, Su-Hyun; Hwang, Seungwoo; Kim, Sungchan; Han, Sung-Jun; Lee, Young Sik
- Issue Date
- 3-10월-2011
- Publisher
- WILEY
- Keywords
- Endogenous siRNA; Dicer-2; Stress response; Lifespan; Metabolic homeostasis; Drosophila
- Citation
- FEBS LETTERS, v.585, no.19, pp.3079 - 3085
- Indexed
- SCIE
SCOPUS
- Journal Title
- FEBS LETTERS
- Volume
- 585
- Number
- 19
- Start Page
- 3079
- End Page
- 3085
- ISSN
- 0014-5793
- Abstract
- Small non-coding RNAs regulate gene expression in a sequence-specific manner. In Drosophila, Dicer-2 (Dcr-2) functions in the biogenesis of endogenous small interfering RNAs (endo-siRNAs). We identified 21 distinct proteins that exhibited a >= 1.5-fold change as a consequence of loss of dcr-2 function. Most of these were metabolic genes implicated in stress resistance and aging. dcr-2 Mutants had reduced lifespan and were hypersensitive to oxidative, endoplasmic reticulum, starvation, and cold stresses. Furthermore, loss of dcr-2 function led to abnormal lipid and carbohydrate metabolism. Our results suggest roles for the endo-siRNA pathway in metabolic regulation and defense against stress and aging in Drosophila. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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