Relationship between the estimates of desaturase activities and cardiometabolic phenotypes in Koreans
- Authors
- Do, Hyun Joo; Chung, Hye Kyung; Moon, Jiyoung; Shin, Min-Jeong
- Issue Date
- 1-9월-2011
- Publisher
- JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
- Keywords
- desaturase; fatty acid composition; cardiometabolic risk factor; inflammation; atherogenic dyslipidemia
- Citation
- JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, v.49, no.2, pp.131 - 135
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- Volume
- 49
- Number
- 2
- Start Page
- 131
- End Page
- 135
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/111605
- DOI
- 10.3164/jcbn.10-147
- ISSN
- 0912-0009
- Abstract
- In the present study, we evaluated the relationships of estimated desaturase activities with cardiometabolic risk factors including abdominal obesity, atherogenic lipoprotein phenotype and inflammation in Koreans. Ninety-three healthy volunteers participated in this cross-sectional study. LDL particle size was determined using gradient gel electrophoresis and inflammatory markers including C-reactive protein, soluble intercellular adhesion molecule-1, and adiponectin were measured. Stearoyl-coA desaturase, delta-6 desaturase and delta-5 desaturase were estimated as precursor to fatty acid ratios. The results showed that stearoyl-coA desaturase was correlated with body mass index (r = 0.235, p<0.05), triglyceride (r = 0.261, p<0.001), and HDL-cholesterol (r = 0.226, p<0.05). Stearoyl-coA desaturase was associated with only triglyceride (r = 0.283, p<0.01). Delta-6 desaturase was correlated with body mass index (r = 0.236, p<0.05), waist circumference (r = 0.218, p<0.05), triglyceride (r = 0.399, p<0.001), C-reactive protein (r = 0.333, p<0.001), soluble intercellular adhesion molecule-1 (r = 0.229, p<0.05), HDL-cholesterol (r = -0.325, p<0.01), LDL particle size (r = -0.297, p<0.01) and adiponectin (r = -0.233, p<0.05). In contrast, delta-5 desaturase was correlated with body mass index (r = -0.324, p<0.01), waist circumference (r = -0.276, p<0.01), triglyceride (r = -0.329, p<0.01), C-reactive protein (r = -0.215, p<0.05), HDL-cholesterol (r = 0.262, p<0.05) and LDL particle size (r = 0.278, p<0.01). Stepwise multiple regression analysis revealed that delta-6 desaturase (p<0.01) together with waist circumference (p<0.001) were found to be independent factors for determining plasma levels of C-reactive protein (R-2 = 0.230). Estimated desaturase activities are closely associated with the features of cardiometabolic risk in Koreans.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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