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Different therapeutic responses in chronic obstructive pulmonary disease subgroups

Authors
Lee, J. S.Huh, J. W.Chae, E. J.Seo, J. B.Ra, S. W.Lee, J-H.Kim, E-K.Lee, Y. K.Kim, T-H.Kim, W. J.Lee, J. H.Lee, S-M.Lee, S.Lim, S. Y.Shin, T. R.Yoon, H. I.Sheen, S. S.Oh, Y-M.Lee, S-D.
Issue Date
8월-2011
Publisher
INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
Keywords
COPD; diffusing capacity; emphysema; lung volume
Citation
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v.15, no.8, pp.1104 - 1110
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
Volume
15
Number
8
Start Page
1104
End Page
1110
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/111938
DOI
10.5588/ijtld.10.0553
ISSN
1027-3719
Abstract
SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classified by diffusing capacity of the lung for carbon monoxide (DLCO) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DLCO and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting beta(2)-agonist (SABA) and 3-month combined inhalation of long-acting beta(2)-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DLCO and RV/TLC, 28 (21.5%) low DLCO and normal RV/TLC, 31 (23.8%) normal DLCO and high RV/TLC, and 30 (23.1%) low DLCO and high RV/TLC. The normal DLCO/high RV/TLC subgroup showed a significantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DLCO/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DLCO/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DLco and RV/TLC may have different pulmonary function responses to pharmacological treatment.
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의과대학 (의학과)
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