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Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part I
- Authors
- Yang, Jee Sun; Song, Doona; Lee, Boah; Ko, Won Jin; Park, Song-Kyu; Won, Misun; Lee, Kiho; Kim, Hwan Mook; Han, Gyoonhee
- Issue Date
- 7월-2011
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Keywords
- Aliphatic amido-quaternary ammonium salts; RhoB; GTPase RAt Sarcoma (Ras); Perifosine; Piperazine alkyl derivatives; NSC126188
- Citation
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.46, no.7, pp.2861 - 2866
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Volume
- 46
- Number
- 7
- Start Page
- 2861
- End Page
- 2866
- ISSN
- 0223-5234
- Abstract
- We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 31 emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents. (C) 2011 Elsevier Masson SAS. All rights reserved.
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