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Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part I

Authors
Yang, Jee SunSong, DoonaLee, BoahKo, Won JinPark, Song-KyuWon, MisunLee, KihoKim, Hwan MookHan, Gyoonhee
Issue Date
7월-2011
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Keywords
Aliphatic amido-quaternary ammonium salts; RhoB; GTPase RAt Sarcoma (Ras); Perifosine; Piperazine alkyl derivatives; NSC126188
Citation
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.46, no.7, pp.2861 - 2866
Indexed
SCIE
SCOPUS
Journal Title
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume
46
Number
7
Start Page
2861
End Page
2866
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/112101
DOI
10.1016/j.ejmech.2011.04.009
ISSN
0223-5234
Abstract
We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 31 emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents. (C) 2011 Elsevier Masson SAS. All rights reserved.
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