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Serum Kisspeptin Levels in Korean Girls with Central Precocious Puberty

Authors
Rhie, Young JunLee, Kee HyoungEun, So HeeChoi, Byung MinChae, Hyun WookKwon, Ah ReumLee, Woo JungKim, Jung HyunKim, Ho-Seong
Issue Date
7월-2011
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Kisspeptin; KISS1 Gene; G-protein Coupled Receptor-54; Central Precocious Puberty; Gonadotropin-Releasing Hormone
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.26, no.7, pp.927 - 931
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
26
Number
7
Start Page
927
End Page
931
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/112137
DOI
10.3346/jkms.2011.26.7.927
ISSN
1011-8934
Abstract
Central precocious puberty (CPP) is caused by premature activation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin and G-protein coupled receptor-54 system is the essential gatekeeper of the reproductive system, playing a key role in the activation of the gonadotropic axis at puberty. We aimed to determine whether serum kisspeptin may function as a marker for CPP by investigating serum kisspeptin levels in Korean girls with CPP and their prepubertal controls. Serum kisspeptin levels of Korean girls with CPP (n = 30) and age-matched healthy prepubertal controls (n = 30) were measured with a competitive enzyme immunoassay. Serum kisspeptin levels were significantly higher in CPP group than in control group (4.61 +/- 1.78 vs 2.15 +/- 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation test. CPP is supposed to be triggered by premature increase of kisspeptin. Serum kisspeptin may be used as a marker of CPP. Further studies on KISS1 gene polymorphisms leading to higher risk of premature increase of kisspeptin and upstream regulator of kisspeptin are also needed.
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