Nanoneedle Transistor-Based Sensors for the Selective Detection of Intracellular Calcium Ions
- Authors
- Son, Donghee; Park, Sung Young; Kim, Byeongju; Koh, Jun Tae; Kim, Tae Hyun; An, Sangmin; Jang, Doyoung; Kim, Gyu Tae; Jhe, Wonho; Hong, Seunghun
- Issue Date
- 5월-2011
- Publisher
- AMER CHEMICAL SOC
- Keywords
- carbon nanotube; field effect transistor; nanoneedle transistor-based sensor; real-time sensor; intracellular calcium ion; Fluo-4-AM dye
- Citation
- ACS NANO, v.5, no.5, pp.3888 - 3895
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS NANO
- Volume
- 5
- Number
- 5
- Start Page
- 3888
- End Page
- 3895
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112508
- DOI
- 10.1021/nn200262u
- ISSN
- 1936-0851
- Abstract
- We developed a nanoneedle transistor-based sensor (NTS) for the selective detection of calcium ions inside a living cell. In this work, a single-walled carbon nanotube-based field effect transistor (swCNT-FET) was first fabricated at the end of a glass nanopipette and functionalized with Fluo-4-AM probe dye. The selective binding of calcium Ions onto the dye molecules altered the charge state of the dye molecules, resulting in the change of the source-drain current of the swCNT-FET as well as the fluorescence intensity from the dye. We demonstrated the electrical and fluorescence detection of the concentration change of intracellular calcium ions inside a HeLa cell using the NTS.
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