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Small-molecule probe using dual signals to monitor leucine aminopeptidase activity
- Issue Date
- 15-4월-2011
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Leucine aminopeptidases; Probe; Dual signals; 2-Dicyanomethylene-3-cyano-2,5-dihydrofuran (DCDHF) unit
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.8, pp.2403 - 2405
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 21
- Number
- 8
- Start Page
- 2403
- End Page
- 2405
- ISSN
- 0960-894X
- Abstract
- Leucine aminopeptidases (LAPs) are widely distributed in organisms from bacteria to humans, and play crucial roles in cell maintenance and cell growth. Thus, assays for LAP are necessary for measuring its activity and inhibitor potency. In this Letter, we report a small-molecule probe which exhibits colorimetric and fluorogenic changes according to LAP activity. (C) 2011 Elsevier Ltd. All rights reserved.
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