Plasma ceruloplasmin as a biomarker for obesity: A proteomic approach
- Authors
- Kim, Oh Yoen; Shin, Min-Jeong; Moon, Jiyoung; Chung, Ji Hyung
- Issue Date
- 4월-2011
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Obesity; Two-dimensional gel electrophoresis; Ceruloplasmin; Biomarker; Proteomics
- Citation
- CLINICAL BIOCHEMISTRY, v.44, no.5-6, pp.351 - 356
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL BIOCHEMISTRY
- Volume
- 44
- Number
- 5-6
- Start Page
- 351
- End Page
- 356
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/112735
- DOI
- 10.1016/j.clinbiochem.2011.01.014
- ISSN
- 0009-9120
- Abstract
- Objectives: This study aimed to investigate new biomarkers of obesity particularly in relation with inflammation-associated proteins using protein differential display techniques. Design and methods: Comparison of protein expression in plasma between non-obese (n=109, body mass index, BMI < 25 kg/m(2)) and obese (n=32, BMI >= 25 kg/m(2)) groups was carried out using two-dimensional gel electrophoresis (2-DE) analysis. ELISA was also performed for validation. Results: Among six differentially expressed protein spots, ceruloplasmin (Cp) and fibrinogen were over-expressed in obese group. Plasma Cp levels were significantly higher in obese group than non-obese group (34.0 +/- 8.6 vs. 41.3 +/- 12.7 mg/dL, p < 0.001) and positively correlated with age (r=0.253, p < 0.005), BMI (r=0.265, p < 0.001) and hsCRP (r=0.385, p < 0.001). In stepwise multiple linear regression analysis, plasma Cp along with hsCRP were found predictors for obesity (adjusted beta-coefficient=0.266, p < 0.01). Conclusion: Elevated plasma Cp levels were significantly associated with obesity, which may be suggested to be a marker of obesity. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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