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14-3-3 eta inhibits chondrogenic differentiation of ATDC5 cell
- Authors
- Yoon, Hee Eun; Kim, Ki Soon; Kim, Ick Young
- Issue Date
- 4-3월-2011
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Chondrogenesis; 14-3-3 eta; Joint inflammation; ATDC5 cells
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.406, no.1, pp.59 - 63
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 406
- Number
- 1
- Start Page
- 59
- End Page
- 63
- ISSN
- 0006-291X
- Abstract
- It was previously shown that 14-3-3 eta is overexpressed in the synovial fluid of patients with joint inflammation, which is often associated with growth failure. In this study, we investigated the role of 14-3-3 eta in chondrogenesis using ATDC5 cells. Upon treatment with TNF-alpha, cells overexpressed 14-3-3 eta with inhibition of chondrogenesis. Chondrogenesis was also inhibited by overexpression of 14-3-3 eta without TNF-a treatment, whereas silencing of 14-3-3 eta promoted chondrogenic differentiation. Further, G1 phase arrest was inhibited by overexpression of 14-3-3 eta. In summary, we suggest that 14-3-3 eta plays a regulatory role in chondrogenic differentiation. (C) 2011 Elsevier Inc. All rights reserved.
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