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Identification and characterization of RNF2 response elements in human kidney cells

Authors
Choi, DongwonKang, Seongman
Issue Date
3월-2011
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Keywords
PcG complex; RNF2; RNF2-responding loci
Citation
MOLECULES AND CELLS, v.31, no.3, pp.247 - 253
Indexed
SCIE
SCOPUS
KCI
Journal Title
MOLECULES AND CELLS
Volume
31
Number
3
Start Page
247
End Page
253
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/113010
DOI
10.1007/s10059-011-0033-7
ISSN
1016-8478
Abstract
RING finger protein 2 (RNF2) contains a conserved Nterminal RING finger domain and functions as an E3 ligase. As a member of the Polycomb group family of proteins, RNF2 also represses a number of genes involved in development, differentiation, malignant transformation and cell cycle. Herein, using chromatin immunoprecipitation cloning, 33 RNF2-responding loci were identified in the genome of HEK293 human kidney cells. Luciferase reporter assays showed that among them, 26 and 2 loci acted as a repressor and an activator, respectively. RNA interference revealed that the identified RNF2-responding sequences regulated the transcriptional activity of nearby promoters. This study may contribute to elucidating the mechanism underlying RNF2-mediated transcriptional regulation.
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