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Identification and characterization of RNF2 response elements in human kidney cells
- Authors
- Choi, Dongwon; Kang, Seongman
- Issue Date
- 3월-2011
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- Keywords
- PcG complex; RNF2; RNF2-responding loci
- Citation
- MOLECULES AND CELLS, v.31, no.3, pp.247 - 253
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MOLECULES AND CELLS
- Volume
- 31
- Number
- 3
- Start Page
- 247
- End Page
- 253
- ISSN
- 1016-8478
- Abstract
- RING finger protein 2 (RNF2) contains a conserved Nterminal RING finger domain and functions as an E3 ligase. As a member of the Polycomb group family of proteins, RNF2 also represses a number of genes involved in development, differentiation, malignant transformation and cell cycle. Herein, using chromatin immunoprecipitation cloning, 33 RNF2-responding loci were identified in the genome of HEK293 human kidney cells. Luciferase reporter assays showed that among them, 26 and 2 loci acted as a repressor and an activator, respectively. RNA interference revealed that the identified RNF2-responding sequences regulated the transcriptional activity of nearby promoters. This study may contribute to elucidating the mechanism underlying RNF2-mediated transcriptional regulation.
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Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
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