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Utilization of glycerol as cysteine and carbon sources for cephalosporin C production by Acremonium chrysogenum M35 in methionine-unsupplemented culture
- Issue Date
- 20-2월-2011
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Cysteine; Acremonium chrysogenum; Methionine; Cephalosporin C
- Citation
- JOURNAL OF BIOTECHNOLOGY, v.151, no.4, pp.363 - 368
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF BIOTECHNOLOGY
- Volume
- 151
- Number
- 4
- Start Page
- 363
- End Page
- 368
- ISSN
- 0168-1656
- Abstract
- In this study, the role of glycerol in cephalosporin C production was evaluated in Acremonium chrysogenum M35. Methionine-unsupplemented culture with glycerol stimulated cephalosporin C production in A. chrysogenum M35 by up to 10-fold while increasing the amount of cysteine. Glycerol caused the upregulation of isopenicillin N-CoA epimerase (cefD2) and delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthase (pcbAB) transcription in exponential phase. These results indicate that glycerol without methionine effectively enhanced cephalosporin C production via stimulation of cysteine and valine in A. chrysogemun M35. (C) 2011 Elsevier B.V. All rights reserved.
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