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Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells
- Authors
- Hong, Seong Su; Lee, Seon A.; Kim, Nahyun; Hwang, Ji Sang; Han, Xiang Hua; Lee, Mi Kyeong; Jung, Jae Kyung; Hong, Jin Tae; Kim, Youngsoo; Lee, Dongho; Hwang, Bang Yeon
- Issue Date
- 15-Feb-2011
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Isodon excisus; Lamiaceae; Pyrrolidinone diterpenoid; Nitric oxide inhibitor
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.4, pp.1279 - 1281
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 21
- Number
- 4
- Start Page
- 1279
- End Page
- 1281
- ISSN
- 0960-894X
- Abstract
- A new pyrrolidinone diterpenoid, excisusin F(1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC50 value of 10.4 and 3.8 mu M, respectively. (C) 2011 Published by Elsevier Ltd.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology