IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor gamma through CAAT/enhancer binding protein beta signaling
- Authors
- Lee, Suk Jun; Lee, Eun Ju; Kim, Sang-Hoon; Choi, Inho; Lee, Dong-Mok; Lee, Hyun-Jeong; Yoon, Duhak; Chun, Taehoon
- Issue Date
- Feb-2011
- Publisher
- SPRINGER
- Keywords
- Adipocyte; IL-17A; Inflammation; Myoblast; Transdifferentiation
- Citation
- BIOTECHNOLOGY LETTERS, v.33, no.2, pp.229 - 235
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOTECHNOLOGY LETTERS
- Volume
- 33
- Number
- 2
- Start Page
- 229
- End Page
- 235
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/113144
- DOI
- 10.1007/s10529-010-0440-4
- ISSN
- 0141-5492
- Abstract
- Helper 17 T (Th17) effector cells are a recently identified Th subset and possess a unique property that distinguishes them from Th1 and Th2 subsets. The functional role of Th17 effector cells involves inflammatory responses, including autoimmunity and infection of specific pathogens. Therefore, IL-17A and its receptors may play a key role in determining the progression of certain inflammatory reactions. However, the relationship between IL-17A and adipogenesis has not yet been examined. Therefore, in this study, the effect of IL-17A on the adipogenic transdifferentiation of mouse myoblast (C2C12) cells was examined. CAAT/enhancer binding-protein beta (C/EPB beta) signaling through the IL-17A receptor promoted adipogenic transdifferentiation of myoblast cells by activating peroxisome proliferator-activated receptor gamma (PPAR gamma). These results will advance our understanding of the physiological function of IL-17A in myoblasts during inflammation, as well as the relationship between adipogenesis and inflammation.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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