The effect of platelet rich plasma from bone marrow aspirate with added bone morphogenetic protein-2 on the achilles tendon-bone junction in Rabbits
- Authors
- Kim, H.J.; Nam, H.-W.; Hur, C.-Y.; Park, M.; Yang, H.S.; Kim, B.-S.; Park, J.-H.
- Issue Date
- 2011
- Publisher
- Korean Orthopaedic Association
- Keywords
- Achilles tendon; Bone marrow derived platelet rich plasma; Bone morphogenetic protein; Bone-tendon junction
- Citation
- Clinics in Orthopedic Surgery, v.3, no.4, pp.325 - 331
- Indexed
- SCOPUS
KCI
OTHER
- Journal Title
- Clinics in Orthopedic Surgery
- Volume
- 3
- Number
- 4
- Start Page
- 325
- End Page
- 331
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/114660
- DOI
- 10.4055/cios.2011.3.4.325
- ISSN
- 2005-291x
- Abstract
- Background: To determine if exogenously injected bone marrow derived platelet-rich plasma (PRP) plus bone morphogenetic protein (BMP)-2 could accelerate the healing of bone-tendon junction injuries and increase the junction holding strength during the early regeneration period. Methods: A direct injury model of the bone-tendon junction was made using an Achilles tendon-calcaneus bone junction in a rabbit. In the PRP/BMP-2/fibrin group, 0.05 mL of bone marrow derived PRP and 100 ng/mL of BMP-2 both incorporated into 0.1 mL of fibrin glue were injected into Achilles tendon-calcaneus bone junctions. The effect of the intervention was tested by comparing the results of an intervention group to a control group. The results of biomechanical testing, and histological and gross analyses were compared between the 2 groups at the following time points after surgery: 2 weeks, 4 weeks, and 8 weeks. Results: Histologic examinations showed that woven bone developed in tendon-bone junctions at 2 weeks after surgery in the PRP/BMP-2/fibrin group. Mechanical test results showed no significant difference between the PRP/BMP-2/fibrin and control groups at 2 and 4 weeks after surgery, but the mean maximal load in the PRP/BMP-2/fibrin group was significantly higher than in the control group (p < 0.05) at 8 weeks after surgery. Conclusions: Bone marrow derived PRP and BMP-2 in fibrin glue accelerated healing in a rabbit model of tendon-bone junction injury. © 2011 by The Korean Orthopaedic Association.
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